Title of article
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid
Author/Authors
Grazyna Cynkowska، نويسنده , , Tadeusz Cynkowski، نويسنده , , Abeer A. Al-Ghananeem، نويسنده , , Hong Guo، نويسنده , , Paul Ashton، نويسنده , , Peter A. Crooks، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3524
To page
3527
Abstract
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.
Keywords
Ethacrynic acid , Timolol , atenolol , prodrug , Codrug , Glaucoma
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795824
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