Title of article
Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol
Author/Authors
Byeong-Seon Jeong، نويسنده , , Nam Song Choi، نويسنده , , Soon Kil Ahn، نويسنده , , Hoon Bae، نويسنده , , Hak-sung Kim، نويسنده , , Deukjoon Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3580
To page
3583
Abstract
Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (−)-2,3-O-isopropylidene-d-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.
Keywords
Fumagillol , angiogenesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795837
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