Title of article
Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis
Author/Authors
Tao Guo، نويسنده , , Yuefei Shao، نويسنده , , Gang Qian، نويسنده , , Laura L. Rokosz، نويسنده , , Tara M. Stauffer، نويسنده , , Rachael C. Hunter، نويسنده , , Suresh D. Babu، نويسنده , , Huizhong Gu، نويسنده , , Doug W. Hobbs، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3696
To page
3700
Abstract
An encoded combinatorial library based on aryl and biaryl piperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biaryl piperidine-based MCH1 receptor antagonists. Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists.
Keywords
MCH , obesity , MCH1R antagonists , Encoded combinatorial synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795862
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