Title of article :
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Author/Authors :
Rong Sheng، نويسنده , , Xiao Lin، نويسنده , , Jingya Li، نويسنده , , Yanke Jiang، نويسنده , , Zhicai Shang، نويسنده , , Yongzhou Hu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
Keywords :
Acetylcholinesterase inhibitors , 2-Phenoxy-indan-1-one derivatives , synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
