Title of article :
Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists
Author/Authors :
Xiaojun Han ، نويسنده , , Jodi A. Michne، نويسنده , , Sokhom S. Pin، نويسنده , , Kevin D. Burris، نويسنده , , Lynn A. Balanda، نويسنده , , Lawrence K. Fung، نويسنده , , Tracey Fiedler، نويسنده , , Kaitlin E. Browman، نويسنده , , Matthew T. Taber، نويسنده , , Jie Zhang، نويسنده , , Gene M. Dubowchik، نويسنده ,
Abstract :
7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.
Keywords :
Corticotropin-releasing factor 1 receptor antagonists , SAR , Anxiolytic activity , Mouse canopy model
