Author/Authors :
Yadagiri Bathini، نويسنده , , SAUL ESTRIN AND ALAN GELB AND INDERJIT SINGH، نويسنده , , Patricia J. Harvey، نويسنده , , Paul R. Keller، نويسنده , , Rajeshwar Singh، نويسنده , , Ronald G. Micetich، نويسنده , , David W. Fry، نويسنده , , Ellen M. Dobrusin، نويسنده , , Peter L. Toogood، نويسنده ,
Abstract :
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.
