Title of article
Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series
Author/Authors
Scott D. Kuduk، نويسنده , , Ronald K. Chang، نويسنده , , Christina Ng، نويسنده , , Kathy L. Murphy، نويسنده , , Richard W. Ransom، نويسنده , , Cuyue Tang، نويسنده , , Thomayant Prueksaritanont، نويسنده , , Roger M. Freidinger، نويسنده , , Douglas J. Pettibone، نويسنده , , Mark G. Bock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3925
To page
3929
Abstract
SAR study of the biphenyl region of 2,3-diaminopyridine bradykinin B1 antagonists was investigated with non-aromatic carbo- and heterocyclic rings. A piperidine ring was found to be a good replacement for the proximal phenyl ring while replacement of the distal phenyl was optimal with a cyclohexyl group leading to a dramatic improvement in affinity for the B1 receptor.
Keywords
Diaminopyridine , bradykinin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795908
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