Title of article
A prodrug system for hydroxylamines based on esterase catalysis
Author/Authors
Ana Conejo-Garcia، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
4004
To page
4009
Abstract
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. γ-Hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Keywords
Prodrug , Lactonisation , esterase , Hydroxylamine , hydroxamates , Intramolecular cyclisation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795922
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