Title of article
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity
Author/Authors
Marie Normand-Bayle، نويسنده , , Christophe Bénard، نويسنده , , Fatima Zouhiri، نويسنده , , Jean-François Mouscadet، نويسنده , , Hervé Leh، نويسنده , , Claire-Marie Thomas، نويسنده , , Gladys Mbemba، نويسنده , , Didier Desmaële، نويسنده , , Jean d’Angelo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4019
To page
4022
Abstract
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays.
Keywords
antivirals , Enzyme inhibitors , Acylation , Quinolines , Metalation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795925
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