Title of article
Identification of heteroarylenamines as a new class of antituberculosis lead molecules
Author/Authors
Brent R. Copp، نويسنده , , Holly C. Christiansen، نويسنده , , Brent S. Lindsay، نويسنده , , Scott G. Franzblau، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
4097
To page
4099
Abstract
Enamine-containing analogues of heteroarylquinones were prepared based on initial screening data observed against Mycobacterium tuberculosis H37Rv (Mtb). Several analogues showed moderate to good inhibitory activity, with one analogue (7) also demonstrating acceptable toxic selectivity (MIC 0.39 μg/mL, SI 15). Activity towards a range of single-drug-resistant strains of Mtb was suggestive of a novel mechanism of action for 7.
Keywords
Antituberculosis activity , Tuberculosis , Quinone , Enamine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795940
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