Author/Authors :
Shuhao Shi، نويسنده , , Shirong Zhu، نويسنده , , Samuel W. Gerritz، نويسنده , , Kim Esposito، نويسنده , , Ramesh Padmanabha، نويسنده , , Wenying Li، نويسنده , , John J. Herbst، نويسنده , , Henry Wong، نويسنده , , Yue-Zhong Shu، نويسنده , , Kin S. Lam، نويسنده , , Michael J. Sofia، نويسنده ,
Abstract :
The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of bacterial and fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient fungal whole-cell assay.
Keywords :
Candida albicans , fungal , antibiotics , Anisomycin library , Staphylococcus aureus , solid-phase synthesis
