Title of article
Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages
Author/Authors
Rika Obata، نويسنده , , Taichi Ohshiro، نويسنده , , Hiroshi Tomoda، نويسنده , , Shigeru Nishiyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
4189
To page
4191
Abstract
Halogenated cyclic isodityrosine–tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.
Keywords
Thallium(III) oxidation , Lipid droplet accumulation inhibitor , Eurypamide , Antiatherosclerotic agents , Cyclic isodityrosine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795955
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