Title of article
4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors
Author/Authors
Junya Ishida، نويسنده , , Kouji Hattori، نويسنده , , Hirofumi Yamamoto، نويسنده , , Akinori Iwashita، نويسنده , , Kayoko Mihara، نويسنده , , Nobuya Matsuoka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4221
To page
4225
Abstract
We have shown that a 4-phenyl-1,2,3,6-tetrahydropyridine fragment plays an important role in improving inhibitory potency against poly(ADP-ribose) polymerase-1 (PARP-1). Various benzamide analogues linked with this fragment via alkyl spacers have been prepared and evaluated. As a result, some of them have been found to be highly potent PARP-1 inhibitors.
Keywords
2 , 3 , poly(ADP-ribose) polymerase , PARP-1 , 4-phenyl-1 , 6-tetrahydropyridine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795962
Link To Document