Author/Authors :
Biswajit Das، نويسنده , , Sonali Rudra، نويسنده , , Ajay Yadav، نويسنده , , Abhijit Ray، نويسنده , , A.V.S. Raja Rao، نويسنده , , A.S.S.V. Srinivas، نويسنده , , Ajay Soni، نويسنده , , Suman Saini، نويسنده , , Shalini Shukla، نويسنده , , Manisha Pandya، نويسنده , , Pragya Bhateja، نويسنده , , Sunita Malhotra، نويسنده , , Tarun Mathur، نويسنده , , S.K. Arora، نويسنده , , Ashok Rattan، نويسنده , , ANITA MEHTA، نويسنده ,
Abstract :
Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the ‘piperazinyl–phenyl–oxazolidinone’ core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible Gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate.
Keywords :
Ranbezolid , Antibacterial , oxazolidinone , RBx 7644 , Nitro-furan derivative
