Title of article
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis
Author/Authors
Kofi A. Oppong، نويسنده , , Christopher D. Ellis، نويسنده , , Michael C. Laufersweiler، نويسنده , , Steven V. O’Neil، نويسنده , , Yili Wang، نويسنده , , David L. Soper، نويسنده , , Mark W. Baize، نويسنده , , John A. Wos، نويسنده , , Biswanath De، نويسنده , , Gregory K. Bosch، نويسنده , , Amy N. Fancher، نويسنده , , Wei Lu، نويسنده , , Maureen K. Suchanek، نويسنده , , Richard L. Wang، نويسنده , , Thomas P. Demuth Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4291
To page
4294
Abstract
A novel diazocan containing dipeptide mimetic was synthesized via reductive N–N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring nitrogen that was used to explore structure-activity relationships in a cell-based assay measuring inhibition of interleukin-1β.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795978
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