Title of article
Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
Author/Authors
Céline Bonnefous، نويسنده , , Jean-Michel Vernier، نويسنده , , John H. Hutchinson، نويسنده , , Michael F. Gardner، نويسنده , , Merryl Cramer، نويسنده , , Joyce K. James، نويسنده , , Blake A. Rowe، نويسنده , , Lorrie P. Daggett، نويسنده , , Herve Schaffhauser، نويسنده , , Theodore M. Kamenecka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4354
To page
4358
Abstract
We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure–activity relationship studies directed toward improving the potency and the brain to plasma ratio of the initial lead led to the discovery of 5 and 23 (EC50 = 111 and 5 nM, respectively).
Keywords
mGluR2 , Indanone , CNS , Schizophrenia
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795992
Link To Document