Title of article
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor
Author/Authors
Joseph Pontillo، نويسنده , , Zhiqiang Guo، نويسنده , , Dongpei Wu، نويسنده , , R. Scott Struthers، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4363
To page
4366
Abstract
Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure–activity relationships of the monocyclic compounds.
Keywords
Synthesis , Triazinedione , GnRH , Azauracil , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795994
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