Title of article :
1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors
Author/Authors :
Christopher D. Beadle، نويسنده , , John Boot، نويسنده , , Nicholas P. Camp، نويسنده , , Nancy Dezutter، نويسنده , , Jeremy Findlay، نويسنده , , Lorna Hayhurst، نويسنده , , John J. Masters، نويسنده , , Roberta Penariol، نويسنده , , Magnus W. Walter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
Keywords :
Monoamine reuptake inhibitors , SAR , Norepinephrine , Quinolin-2-one , Pharmacophore , Selective norepinephrine reuptake inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
