Title of article
Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives
Author/Authors
Tanushree Ratan Bal، نويسنده , , Balasubramani Anand، نويسنده , , Perumal Yogeeswari، نويسنده , , Dharmarajan Sriram، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
4451
To page
4455
Abstract
On the basis of pharmacophoric modelling studies of existing NNRTIs, a series of isatin β-thiosemicarbazone derivatives was synthesized and evaluated for their anti-HIV activity in HTLV-IIIB strain in the CEM cell line. Three compounds showed significant anti-HIV activity, whereupon compound 6 was found to be the most active compound with an EC50 value of 2.62 μM and a selectivity index of 17.41, while not being cytotoxic to the cell line at a CC50 value of 44.90 μM. Other tested compounds exhibited marked activity below their toxicity threshold.
Keywords
Anti-HIV , Isatin , thiosemicarbazones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796008
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