Title of article
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands
Author/Authors
Guangrong Zheng، نويسنده , , Linda P. Dwoskin، نويسنده , , Agripina G. Deaciuc، نويسنده , , Peter A. Crooks، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4463
To page
4466
Abstract
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at α4β2* and α7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.
Keywords
VMAT2 ligands , Psychostimulant abuse , Tropane analogues
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796011
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