Title of article
Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents
Author/Authors
Gui-Bai Liang، نويسنده , , Xiaoxia Qian، نويسنده , , Tesfaye Biftu، نويسنده , , Dennis Feng، نويسنده , , Michael Fisher، نويسنده , , Tami Crumley، نويسنده , , Sandra J. Darkin-Rattray، نويسنده , , Paula M. Dulski، نويسنده , , Anne Gurnett، نويسنده , , Penny Sue Leavitt، نويسنده , , Paul A. Liberator، نويسنده , , Andrew S. Misura، نويسنده , , Samantha Samaras، نويسنده , , Tamas Tamas، نويسنده , , Dennis M. Schmatz، نويسنده , , Matthew Wyvratt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4570
To page
4573
Abstract
Diaryl-(4-piperidinyl)-pyrrole derivatives bearing hydroxylated N-alkyl substituents have been synthesized and evaluated as anticoccidial agents. High potency in Et-PKG inhibition and broad-spectrum anticoccidial activities have been observed on compounds, such as 4b and 5h, which are fully efficacious in vivo at 50 ppm in feed.
Keywords
Coccidiosis , PKG inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796035
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