Author/Authors :
Clementina Manera، نويسنده , , Laura Betti، نويسنده , , Tiziana Cavallini، نويسنده , , Gino Giannaccini، نويسنده , , Adriano Martinelli، نويسنده , , Gabriella Ortore، نويسنده , , Giuseppe Saccomanni، نويسنده , , Maria Letizia Trincavelli، نويسنده , , Tiziano Tuccinardi، نويسنده , , Pier Luigi Ferrarini، نويسنده ,
Abstract :
A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.
