Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
Author/Authors :
Stefan Weigand، نويسنده , , Hilmar Bischoff، نويسنده , , Elke Dittrich-Wengenroth، نويسنده , , Heike Heckroth، نويسنده , , Dieter Lang، نويسنده , , Andrea Vaupel، نويسنده , , Michael Woltering، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
5
From page :
4619
To page :
4623
Abstract :
We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor δ (PPARδ) based on a lead structure from our PPARα program. Compound 33 showed good pharmacokinetics.
