Title of article
Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein
Author/Authors
Fedele Manna، نويسنده , , Franco Chimenti، نويسنده , , Rossella Fioravanti، نويسنده , , Adriana Bolasco، نويسنده , , Daniela Secci، نويسنده , , Paola Chimenti، نويسنده , , Cristiano Ferlini، نويسنده , , Giovanni Scambia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4632
To page
4635
Abstract
A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.
Keywords
Anticancer , Pyrazoline , P-glycoprotein
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796048
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