Title of article :
Potential metabolites of a condensed 2,3-benzodiazepine derivative
Author/Authors :
Emese Csuzdi، نويسنده , , Katalin Migléczi، نويسنده , , Istv?n Hazai، نويسنده , , P?l Berzsenyi، نويسنده , , Istv?n Pallagi، نويسنده , , Gyula Horv?th، نويسنده , , Gy?rgy Lengyel، نويسنده , , S?ndor S?lyom، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Putative metabolites of an AMPA antagonist imidazo-2,3-benzodiazepine (2) were synthesized and compared to constituents formed from the parent compound by a rat liver perfusion method. As metabolic transformations, hydroxylation of the 2-methyl group and N-acetylation of the amino functionality in parent compound (2) were registered. The hydroxylated analogue 12 of 2 exhibits a weak AMPA antagonist activity.
Keywords :
HPLC/MS analysis , Metabolite , 3]benzodiazepine , AMPA antagonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
