Author/Authors :
Evgueni L. Piatnitski، نويسنده , , Matthew A.J. Duncton، نويسنده , , Alexander S. Kiselyov، نويسنده , , Reeti Katoch-Rouse، نويسنده , , Dan Sherman، نويسنده , , Daniel L. Milligan، نويسنده , , Chris Balagtas، نويسنده , , Wai C. Wong، نويسنده , , Joel Kawakami، نويسنده , , Jacqueline F. Doody، نويسنده ,
Abstract :
A novel class of 4-arylamino-phthalazin-1-yl-benzamides is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display potent VEGFR-2 inhibitory activity with an IC50 as low as 0.078 μM in an HTRF enzymatic assay. These compounds are relatively selective against a small kinase panel.
Keywords :
Vascular endothelial growth factor , kinase inhibitor , Phthalazine , angiogenesis
