Title of article
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors
Author/Authors
Noel A. Powell، نويسنده , , Emma H. Clay، نويسنده , , Daniel D. Holsworth، نويسنده , , John W. Bryant، نويسنده , , MICHAEL J. RYAN، نويسنده , , Mehran Jalaie، نويسنده , , Jeremy J. Edmunds، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4713
To page
4716
Abstract
Inhibition of renin enzymatic activity by a series of ketopiperazine-based compounds containing a C6 benzyloxymethyl substituent correlated with a +(π + σ) effect. A 3-pyridinyloxymethyl substituent was also found to be equipotent as higher molecular weight analogs, and exhibited decreased CYP3A4 inhibition levels and improved pharmacokinetic properties.
Keywords
Topliss tree , renin inhibitor , hypertension
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796061
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