Title of article
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Author/Authors
Bernard Hulin، نويسنده , , Shawn Cabral، نويسنده , , Michael G. Lopaze، نويسنده , , Maria A. Van Volkenburg، نويسنده , , Kim M. Andrews، نويسنده , , Janice C. Parker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4770
To page
4773
Abstract
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.
Keywords
Dipeptidyl peptidase IV , Cyclohexylglycine , Difluoropyrrolidine , Tetrafluoropyrrolidine , Fluoroazetidine , Difluoroazetidine , DPP-IV
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796072
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