Author/Authors :
Brian E. Fink، نويسنده , , Gregory D. Vite، نويسنده , , Harold Mastalerz، نويسنده , , John F. Kadow، نويسنده , , Soong-Hoon Kim، نويسنده , , Kenneth J. Leavitt، نويسنده , , Karen Du، نويسنده , , Donald Crews، نويسنده , , Toomas Mitt، نويسنده , , Tai W. Wong، نويسنده , , John T. Hunt، نويسنده , , Dolatrai M. Vyas، نويسنده , , John S. Tokarski، نويسنده ,
Abstract :
A novel series of dual EGFR and HER2 inhibitors based on the pyrrolo[2,1-f][1,2,4]triazine nucleus is described. A general route toward their synthesis, which enables functionalization at multiple sites, has been developed. Biological evaluation in enzymatic and cell-based assays has identified a series of C-6 carbamates with potent biochemical and cellular activities.
