Author/Authors :
Joseph Dudash Jr.، نويسنده , , Yongzheng Zhang، نويسنده , , John B. Moore، نويسنده , , Richard Look، نويسنده , , Ling-Yin Liang، نويسنده , , Mary Pat Beavers، نويسنده , , Bruce R. Conway، نويسنده , , Philip J. Rybczynski، نويسنده , , Keith T. Demarest، نويسنده ,
Abstract :
A series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors. The lead compound 1 was identified through high throughput screening as well as through pharmacophore-based electronic screening. Modifications were made to the scaffold of 1 to produce novel analogues, some of which are 25 times more potent than the lead compound.
