Title of article
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
Author/Authors
Huasheng Ding، نويسنده , , Chao Zhang، نويسنده , , Xihan Wu، نويسنده , , Chunhao Yang، نويسنده , , Xiongwen Zhang، نويسنده , , Jian Ding، نويسنده , , Yuyuan Xie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4799
To page
4802
Abstract
In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results indicate that substitutes on the γ-position of lactones have a rather significant influence on inhibition activities.
Keywords
Indole ?-methylene-?-lactones , inhibitors , AKT-mTOR signaling pathway kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796078
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