Title of article
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology
Author/Authors
Yoichi Takakusagi، نويسنده , , Keisuke Ohta، نويسنده , , Kouji Kuramochi، نويسنده , , Kengo Morohashi، نويسنده , , Susumu Kobayashi، نويسنده , , Kengo Sakaguchi، نويسنده , , Fumio Sugawara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4846
To page
4849
Abstract
A biotinylated derivative of the anti-tumor agent camptothecin (CPT) was synthesized and used in a phage display assay to identify drug-binding sequences. After three rounds of selection using C20-biotinylated CPT (CPT-20-B) as bait, a CPT-20-B-binding sequence, NSSQSARR, was identified.
Keywords
camptothecin , phage display , biotin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796089
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