Title of article
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents
Author/Authors
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , S. Sinha، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4923
To page
4926
Abstract
A library of 30 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the 30 compounds synthesized, 23 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25–2 μg/mL and 16 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 25 μg/mL.
Keywords
malaria , Dihydrofolate reductase , Solid support synthesis , combinatorial chemistry
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796102
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