Title of article
Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents
Author/Authors
Sanjay Babu Katiyar، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
4957
To page
4960
Abstract
A series of 22 compounds were synthesized and screened against Plasmodium falciparum NF-54 strain. Of the screened compounds, 6 compounds showed MIC in the range between 1 and 2 μg/mL. These compounds are 32 times more potent than the cycloguanil which was used as the standard drug.
Keywords
dihydrofolate reductase , Antimalarial , Pyrazolyl triazine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796109
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