Title of article
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor
Author/Authors
Gilles C. Bignan، نويسنده , , Kathleen Battista، نويسنده , , Peter J. Connolly، نويسنده , , Michael J. Orsini، نويسنده , , Jingchun Liu، نويسنده , , Steven A. Middleton، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5022
To page
5026
Abstract
A novel series of indolin-2-ones having a spirocyclic piperidine ring at the 3-position was synthesized and found to bind with high affinity to the ORL-1 receptor. Structure–activity relationships at the piperidine nitrogen were investigated. Substitution on the phenyl ring and nitrogen atom of the indolin-2-one core generated several selective high-affinity ligands that were antagonists of the ORL-1 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796122
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