Author/Authors :
James F. Dropinski، نويسنده , , Taro Akiyama، نويسنده , , Monica Einstein، نويسنده , , Bahanu Habulihaz، نويسنده , , Tom Doebber، نويسنده , , Joel P. Berger، نويسنده , , Peter T. Meinke، نويسنده , , Guo Q. Shi، نويسنده ,
Abstract :
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
