Title of article
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis
Author/Authors
Fabrice Bailly، نويسنده , , Clémence Queffelec، نويسنده , , Gladys Mbemba، نويسنده , , Jean-François Mouscadet، نويسنده , , Philippe Cotelle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5053
To page
5056
Abstract
The synthesis of two caffeoyl-coumarin conjugates, derived from sagecoumarin, has been accomplished, starting from ferulic acid, isoferulic acid and sesamol. Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3′-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-β-gal-CD4+ cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796129
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