Title of article
Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity
Author/Authors
Jun F. Liang، نويسنده , , Victor C. Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5071
To page
5075
Abstract
Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin–TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin–TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.
Keywords
tumor , Drug resistance , P-glycoprotein , Conjugates , Anticancer drug , cell penetrating peptide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796133
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