• Title of article

    Synthesis of desthio prenylcysteine analogs: Sulfur is important for biological activity

  • Author/Authors

    Brian S. Henriksen، نويسنده , , Jessica L. Anderson، نويسنده , , Christine A. Hrycyna، نويسنده , , Richard A. Gibbs، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    4
  • From page
    5080
  • To page
    5083
  • Abstract
    N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of 325 μM.
  • Keywords
    Enzyme inhibitors , Isoprenoids , methyltransferase , Amino acid analogs
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2005
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    796135

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796135