Author/Authors :
Britt-Marie Swahn، نويسنده , , Fernando Huerta، نويسنده , , Elisabet Kallin، نويسنده , , Jonas Malmstr?m، نويسنده , , Tatjana Weigelt، نويسنده , , Jenny Viklund، نويسنده , , Patrick Womack، نويسنده , , Yafeng Xue، نويسنده , , Liselotte ?hberg، نويسنده ,
Abstract :
The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38α is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.
Keywords :
c-Jun N-terminal kinase-3 , JNK3 inhibitors , Structure based design , 6-Anilinoindazoles
