Title of article
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents
Author/Authors
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , S. Sinha، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5218
To page
5221
Abstract
A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25–2 μg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 μg/mL.
Keywords
combinatorial chemistry , malaria , solid phase synthesis , Dihydrofolate reductase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796159
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