Title of article
Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists
Author/Authors
Anandan Palani، نويسنده , , Sherry Shapiro، نويسنده , , Mark D. McBriar، نويسنده , , John W. Clader، نويسنده , , William J. Greenlee، نويسنده , , Kim O’Neill، نويسنده , , Brian Hawes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
5234
To page
5236
Abstract
Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series.
Keywords
MCH-R1 antagonists , Melanin concentrating hormone receptor 1 antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796163
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