Title of article
Structure–activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor
Author/Authors
Joseph Pontillo، نويسنده , , Joe A. Tran، نويسنده , , Nicole S. White، نويسنده , , Melissa Arellano، نويسنده , , Beth A. Fleck، نويسنده , , Dragan Marinkovic، نويسنده , , Fabio C. Tucci، نويسنده , , John Saunders، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5237
To page
5240
Abstract
Synthesis and structure–activity relationship studies of a series of cyclohexylpiperazines bearing an amide side chain as ligands of the MC4 receptor are discussed. Compounds such as 11i from this series are potent agonists (EC50 = 33 nM, IA = 96%).
Keywords
receptor , Melanocortin-4 , agonist , synthesis , Cyclohexylpiperazine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796164
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