Title of article
N-[(3S)-1-Benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human dopamine D4 ligands with high affinity for the 5-HT2A receptor
Author/Authors
Jalaj Arora، نويسنده , , Michel Bordeleau، نويسنده , , Laurence Dube، نويسنده , , Keith Jarvie، نويسنده , , Lucy Mazzocco، نويسنده , , Jack Peragine، نويسنده , , Ashok Tehim، نويسنده , , Ian Egle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
5253
To page
5256
Abstract
A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D4 (hD4) and 5-HT2A receptors. Several compounds displayed selectivity for these receptors versus hD2 and α1 adrenergic receptors of over 500-fold.
Keywords
Serotonin , D4 , Schizophrenia , 5-HT2A , Dopamine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796167
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