Title of article
N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase
Author/Authors
Sabine Gavalda، نويسنده , , Rémi Braga، نويسنده , , Chantal Dax، نويسنده , , Alain Vigroux، نويسنده , , Casimir Blonski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
5375
To page
5377
Abstract
Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.
Keywords
Fructose bisphosphate aldolase , inhibitors , phosphonate , N-Sulfonyl hydroxamate derivatives
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796190
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