Title of article
Novel triazole based inhibitors of Ras farnesyl transferase
Author/Authors
Ashis K. Saha، نويسنده , , Li Liu، نويسنده , , Richard Simoneaux، نويسنده , , Bart DeCorte، نويسنده , , Christophe Meyer، نويسنده , , Stacy Skrzat، نويسنده , , Henry J. Breslin، نويسنده , , Michael J. Kukla، نويسنده , , Dave W. End، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5407
To page
5411
Abstract
A novel series of potent inhibitors of Ras farnesyl transferase possessing a 1,2,4-triazole pharmacophore is described. These inhibitors were discovered from a parallel synthesis effort and were subsequently optimized to in vitro IC50 value of less than 1 nM.
Keywords
parallel synthesis , ras , Farnesyl transferase , triazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796197
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