Title of article
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands
Author/Authors
Peter Grundt، نويسنده , , Theresa A. Kopajtic، نويسنده , , Jonathan L. Katz، نويسنده , , Amy Hauck Newman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5419
To page
5423
Abstract
A series of N-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (DAT), serotonin (SERT), norepinephrine (NET) transporters, and muscarinic M1 receptors. In general, the isosteric replacement of the C-3 benzhydrol ether of benztropine by a benzhydryl amino group was well tolerated at the DAT. However, for certain N-8 substituted derivatives, selectivity over muscarinic M1 receptor affinity was reduced.
Keywords
Monoamine transporters , Dopamine transporters , Cocaine , Muscarinic M1 receptor , Benztropine , Benztropinamine , Ligand binding
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796199
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