Title of article
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors
Author/Authors
Steven V. O’Neil، نويسنده , , Yili Wang، نويسنده , , Michael C. Laufersweiler، نويسنده , , Kofi A. Oppong، نويسنده , , David L. Soper، نويسنده , , John A. Wos، نويسنده , , Christopher D. Ellis، نويسنده , , Mark W. Baize، نويسنده , , Gregory K. Bosch، نويسنده , , Amy N. Fancher، نويسنده , , Wei Lu، نويسنده , , Maureen K. Suchanek، نويسنده , , Richard L. Wang، نويسنده , , Biswanath De، نويسنده , , Thomas P. Demuth Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5434
To page
5438
Abstract
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors, with numerous compounds exhibiting caspase-1 IC50s less than 10 nM.
Keywords
Interleukin-1 converting enzyme inhibitors , caspase , Peptidomimetic , Olefin metathesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796202
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