Title of article
Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists
Author/Authors
Istv?n Borza، نويسنده , , S?ndor Kolok، نويسنده , , Gy?rgyi Ign?cz-Szendrei، نويسنده , , Istv?n Greiner، نويسنده , , G?bor T?rk?nyi، نويسنده , , Kornél Galg?czy، نويسنده , , Csilla Horv?th، نويسنده , , S?ndor Farkas، نويسنده , , Gy?rgy Dom?ny، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
5439
To page
5441
Abstract
A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse.
Keywords
NB2B , Indole-2-carboxamidine , NMDA
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796203
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