Title of article
Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids
Author/Authors
Mark R. Spyvee، نويسنده , , Huiming Zhang، نويسنده , , Lynn D. Hawkins، نويسنده , , Jesse C. Chow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5494
To page
5498
Abstract
Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.
Keywords
TLR2 , TLR2 antagonist , Synthetic phospholipid , Toll-like receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796215
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